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When a witness is inexplicably murdered in a locked room at a federal courthouse, Dr. Lee Rosen is put on the case. He leads a team of "Alphas", human beings with enhanced abilities due to differences in their brain structure: Gary Bell, a highly functioning autistic with an ability to process information that rivals most computers; Bill Harken, a former FBI agent who can amp up his "fight or flight" reflex, giving him extraordinary strength for a brief period of time; Nina Theroux, a beautiful woman who can reprogram other people's minds to do as she bids; and Rachel Pirzad, a sheltered Persian girl who can intensify one sense at the expense of the others. However, with said powers comes a price -